Erika Borgonovo Barrote
Master's – Barriers and facilitators to technological innovation: laboratory techniques without the use of animals in research
Advisor: Prof. Dr. Eduardo Pinheiro Gondim de Vasconcellos
Comission: Profs. Drs. Isak Kruglianskas, Silvya Stuchi Maria Engler and Luiz Antonio Bloem da Silveira Juniori
Link YouTube: https://youtu.be/8WXHl2o9_1A
Technology is changing rapidly, forcing associations to adapt. Today's world provides rapid and wide dissemination of information and as a result, people become more aware of the impacts of humanity on other species and the planet. This trend also affects the scientific area, which is under pressure to end tests and laboratory experiments carried out on animals. In 1959, the concept of substitution tests, as alternatives to the use of animals, appears. Today, this concept is the basis for several alternative laboratory methodologies validated abroad and accepted in Brazil. Besides, many products tested and approved in different species are incapable of repeating their results in humans, losses in financial losses to the industry, damage to consumers' health, and the useless sacrifice of animals. In Brazil, the religion of September 2019 imposing the adoption of 17 methodologies by all laboratories, forcing them to abandon or reduce the use of animals for some purposes. This study aims to determine the main barriers and the most relevant facilitators for research laboratories to abandon animal methods and adopt alternative methods. The research was conducted through semi-structured interviews, based on factors that can act as facilitators and barriers to alternative methods adopting, from the literature on business administration and the laboratory. The professionals interviewed belong, in equal proportion, to private companies and public laboratories that carry out alternative methods that predict the effects of substances on ocular or skin tissue. Subsequently, results were qualitatively analyzed, and some of the collected data was submitted to non-parametric analysis to determine the agreement between responses from subgroups within the sample. The most important barriers to adopting alternative methods are the high costs and difficulty in validating these technologies. The most relevant enablers are the social pressure that affects the company's brand, the collaboration between institutions, and the speed of carrying out alternative methods. Among the subgroups of methodology users, there was a difference between the most important barriers and total agreement for the prominent facilitators. Among the subgroups of researchers from the private and public segments, there was disagreement regarding the most important barriers and partial agreement regarding the facilitators.
*Abstract provided by the author